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卵巢癌

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免疫记忆

B细胞
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研究证实：卵巢癌患者体内 抗癌“免疫记忆”细胞长存

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责任编辑: 国际小编

（特拉维夫9日综合电）以色列一项新研究显示，在卵巢癌患者体内长期存在对肿瘤细胞具有“免疫记忆”的B细胞，当再次遭遇入侵的肿瘤细胞时，它们能迅速部署定向“防御武器”，即产生能够特异性结合肿瘤细胞的有效抗体。这一发现为开发癌症免疫疗法及预防癌症复发提供了新思路。

以色列魏茨曼科学研究所近日发布公报说，该机构研究人员领衔的团队对11名高级别浆液性卵巢癌患者肿瘤样本及邻近淋巴结中的免疫细胞进行了分析，发现这些淋巴结中存在具有免疫记忆的B细胞，它们携带可识别肿瘤的抗体遗传信息。实验显示，这些B细胞产生的抗体中超过三分之一能够强效结合卵巢癌细胞，而对人体自身健康细胞结合能力较弱，表明其具有较强靶向性。

研究发现，这类记忆B细胞可能在肿瘤附近的淋巴结中长期存在，但在淋巴结内并未表现出活跃免疫反应。在需要时，它们可以从淋巴结迁移至肿瘤部位并被激活，从而持续参与针对癌症的免疫反应。研究还显示，部分记忆B细胞产生的抗体针对的是卵巢癌扩散所依赖的关键蛋白。由于癌细胞难以通过突变完全摆脱这类关键蛋白，因此相关抗体可能提供长期免疫保护。

为何具有免疫记忆的B细胞在淋巴结中未能被激活？研究确认，一类名为巨噬细胞的免疫细胞会抑制淋巴结内B细胞的活化。




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免疫记忆

B细胞

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对于大多数卵巢癌患者，现有免疫疗法效果普遍不理想。研究人员表示，这一新发现可能为改善相关治疗提供新的方向。研究表明，人体或具备对癌症形成长期免疫记忆的能力，不仅可能据此开发出针对癌症的新型免疫疗法，还有望推动癌症免疫疗法从治疗用途进一步扩展至预防复发领域。未来若能调控这类B细胞活性，也可能用于抑制自身免疫性疾病中过度活跃的免疫反应等。<\/p>\n\n\n\n
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